Biophysical Characterization of Anticoagulant Hemextin AB Complex from the Venom of Snake Hemachatus haemachatus
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چکیده
منابع مشابه
Partial Purification and Characterization of Anticoagulant Factor from the Snake (Echis carinatus) Venom
Objective(s): Snake venoms contain complex mixture of proteins with biological activities. Some of these proteins affect blood coagulation and platelet function in different ways. Snake venom toxin may serve as a starting material for drug design to combat several pathophysiological problems such as cardiovascular disorders. In the present study, purification of anticoagulation facto...
متن کاملSnake venom toxins. Purification, properties, and complete amino acid sequence of two toxins from Ringhals (Hemachatus haemachatus) venom.
Two toxins, designated Hemachatus haemachatus toxins II and IV, have been isolated from the venom of the South African Ringhals (H. haemachatus) by gradient chromatography on A.mberlite CG-50, and have been further purified by gel filtration on Sephadex G-50. The toxins are essentially homogeneous by free boundary electrophoresis, ultracentrifugation, and amino acid analyses. Toxins II and IV h...
متن کاملIdentification and Structural Characterization of a New Three-Finger Toxin Hemachatoxin from Hemachatus haemachatus Venom
Snake venoms are rich sources of biologically active proteins and polypeptides. Three-finger toxins are non-enzymatic proteins present in elapid (cobras, kraits, mambas and sea snakes) and colubrid venoms. These proteins contain four conserved disulfide bonds in the core to maintain the three-finger folds. Although all three-finger toxins have similar fold, their biological activities are diffe...
متن کاملpartial purification and characterization of anticoagulant factor from the snake (echis carinatus) venom
objective(s): snake venoms contain complex mixture of proteins with biological activities. some of these proteins affect blood coagulation and platelet function in different ways. snake venom toxin may serve as a starting material for drug design to combat several pathophysiological problems such as cardiovascular disorders. in the present study, purification of anticoagulation factor from veno...
متن کاملExactin: A specific inhibitor of Factor X activation by extrinsic tenase complex from the venom of Hemachatus haemachatus
Unwanted clots lead to heart attack and stroke that result in a large number of deaths. Currently available anticoagulants have some drawbacks including their non-specific actions. Therefore novel anticoagulants that target specific steps in the coagulation pathway are being sought. Here we describe the identification and characterization of a novel anticoagulant protein from the venom of Hemac...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2007
ISSN: 0006-3495
DOI: 10.1529/biophysj.106.100164